Oral Aciclovir Tablets 200mg / 400mg For Herpes Simplex Virus
Product : Aciclovir Tablets
Specification : 100mg, 200mg, 400mg
Standard : BP, USP
Packing : 10’s/blister
A guanosine analog antiviral drug that acts as an antimetabolite.
Aciclovir is used for the treatment of herpes simplex virus
infections, varicella zoster (chickenpox) and herpes zoster
Aciclovir has also been investigated for the treatment of herpes
labialis applied using an iontophoretic device. Currently approved
drugs for the treatment of herpes labialis (cold sores) exhibit low
levels of efficacy due to the limited ability of the drugs to
penetrate the skin to the site where the herpes virus is
replicating. Iontophoresis uses electric current to enhance the
delivery of drugs through the skin.
For the treatment and management of herpes zoster (shingles),
genital herpes, and chickenpox.
Aciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic
deoxyguanosine analog and it is the prototype antiviral agent that
is activated by viral thymidine kinase. The selective activity of
aciclovir is due to its affinity for the thymidine kinase enzyme
encoded by HSV and VZV. EC50 value of acyclovir against clinical
herpes virus isolates was 1.3 μM (range: < 0.56 to 3.3 μM).
Mechanism of action :
Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to
the aciclovir monophosphate, which is then converted to the
diphosphate by cellular guanylate kinase, and finally to the
triphosphate by phosphoglycerate kinase, phosphoenolpyruvate
carboxykinase, and pyruvate kinase. Aciclovir triphosphate
competitively inhibits viral DNA polymerase and competes with the
natural deoxyguanosine triphosphate, for incorporation into viral
DNA. Once incorporated, aciclovir triphosphate inhibits DNA
synthesis by acting as a chain terminator. One may consider
aciclovir to be a prodrug as it is metabolized to more active
compounds. Aciclovir is selective and low in cytotoxicity as the
cellular thymidine kinase of normal, uninfected cells does not use
aciclovir effectively as a substrate.