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Oral Aciclovir Tablets 200mg / 400mg For Herpes Simplex Virus Infections

Categories Oral Medications
Brand Name: Newlystar
Place of Origin: China
MOQ: Two million tablets
Payment Terms: L/C, T/T
Delivery Time: 45days
Packaging Details: 10’s/blister
Model Number: 100mg, 200mg, 400mg
Certification: GMP
Price: Negotiation
Supply Ability: One million tablets per day
Product: Aciclovir Tablets
Specification: 100mg, 200mg, 400mg
Standard: BP, USP
Packing: 10’s/blister
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    Oral Aciclovir Tablets 200mg / 400mg For Herpes Simplex Virus Infections

    Oral Aciclovir Tablets 200mg / 400mg For Herpes Simplex Virus Infections

    Product : Aciclovir Tablets

    Specification : 100mg, 200mg, 400mg

    Standard : BP, USP

    Packing : 10’s/blister

    Description :

    A guanosine analog antiviral drug that acts as an antimetabolite. Aciclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles).

    Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.

    Indication :

    For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.

    Pharmacodynamics :

    Aciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of aciclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. EC50 value of acyclovir against clinical herpes virus isolates was 1.3 μM (range: < 0.56 to 3.3 μM).

    Mechanism of action :

    Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. One may consider aciclovir to be a prodrug as it is metabolized to more active compounds. Aciclovir is selective and low in cytotoxicity as the cellular thymidine kinase of normal, uninfected cells does not use aciclovir effectively as a substrate.

    Product Tags:

    oral medicine


    oral treatment

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